2 edition of "in vivo" measurement of lead and platinum in the kidney found in the catalog.
"in vivo" measurement of lead and platinum in the kidney
Andrew Christian Todd
Thesis (Ph.D.)-University of Birmingham, School of Physics and Space Research.
|Statement||Andrew Christian Todd.|
There is still no perfect in vitro or ex vivo model for studying nephrotoxicity in the human kidney. However, several advances have been proposed. However, several advances have been proposed. Most recently, studies have proposed the use of kidney on a chip and microdialysis (Gozalpour and Fenner, ; Lee and Kim, ). Four invasive UC cell lines, T24, , and their corresponding sublines T24PR and PR with acquired platinum resistance, were assessed by microarray, and the ubiquitin E3 ligase FBXO32 was newly identified as a negative regulator of EMT in UC tumors after acquisition of platinum resistance. In vitro and in vivo studies showed an intimate.
The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and copper deficiency is detrimental to many important cellular functions, but excess copper is toxic. Recent research has revealed that human copper homeostasis is tightly controlled by interregulatory circuitry involving copper, Sp1, and. Measurement of renal perfusion is a crucial part of measuring kidney function. Arterial spin labelling magnetic resonance imaging (ASL MRI) is a non-invasive method of measuring renal perfusion using magnetised blood as endogenous contrast. We studied the reproducibility of ASL MRI in normal volunteers. ASL MRI was performed in healthy volunteers on 2 occasions using a Tesla .
Acute or short-term in vivo bioassays that have been described for LH are the ovarian ascorbic acid depletion test and the measurement of peripheral testosterone levels (, ). When preparations of different molecular composition are compared with each other in these two assays, different relative potencies are derived depending upon the. Radiometer’s new acute care testing handbook is available as an e-book offering a practical guide to critical parameters in acute care testing such as pO 2, lactate and troponin. The e-book format is supported by a wide range of e-book reader devices and e-book .
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A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead. In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using 99mTc in a backscatter by: 2.
The pretreatment measurement was negative for any heavy metal deposit, but 1 day after cisplatin infusion the kidney lead peaks were equivalent to [plusmn] 48 [micro]g/g. A month later the measurement was repeated and the lead concentration had fallen to + 47 [micro]g/ by: An X-ray fluorescence technique for in vivo determination of lead concentration in a bone matrix.
Phys Med Biol. Jan; 24 (1)– Somervaille LJ, Chettle DR, Scott MC, Tennant DR, McKiernan MJ, Skilbeck A, Trethowan WN. In vivo tibia lead measurements as an index of cumulative exposure in occupationally exposed subjects. Todd AC, Chettle DR, Scott MC, Somervaille LJ () A pilot study using 99mTc to measure lead and platinum in the human kidney.
Nucl Med Biol – PubMed Google ScholarCited by: (O’Meara et al), lead in bone (Börjesson and Mattsson ) and cadmium (Ahlgren and Mattsson ) in the kidney. Other in vivo XRF systems have probed gold in the kidney and liver (Börjesson et al ) and platinum in the neck (Jonson et al ).
The current work reports on the first performance comparison of two candidate approaches toCited by: 8. 1. Introduction. In recent decades, the number of kidney patients has increased significantly .Kidney disease can be broadly classified into acute kidney injury (AKI) and chronic kidney disease (CDK) .However, it is believed that AKI and CKD are closely linked and likely promote one another .CKD is a significant public health issue worldwide , In a recent meta-analysis on.
Palladium is a chemical element with the symbol Pd and atomic number It is a rare and lustrous silvery-white metal discovered in by the English chemist William Hyde named it after the asteroid Pallas, which was itself named after the epithet of the Greek goddess Athena, acquired by her when she slew ium, platinum, rhodium, ruthenium, iridium and osmium form a.
Cadmium in man measured in vivo by X-ray fluorescence analysis L Ahlgren and S Mattsson-A method for in vivo analysis of platinum after chemotherapy: with cisplatin R Jonson, S Mattsson and B Unsgaard-In vivo XRF analysis of mercury: the relation between concentrations in the kidney and the urine J Borjesson, L Barregard, G Sallsten et al.
have been used to measure iodine in the thyroid, lead in bone and cadmium in kidney and liver (Hoffer et a1Ahlgren etalChristoffersson and MattssonSomervaille et alBorjesson etal ). Reports on in vivo studies of platinum in the kidney and. Keith E. Levine's 79 research works with citations and 4, reads, including: Erythrocyte Levels of Cadmium and Lead and Risk of B‐Cell Non‐Hodgkin Lymphoma and Multiple Myeloma.
Not every element in the periodic table is vital to sustain human life, and exposure to some elements may result in pathology. As the kidney is one of the main routes of excretion, it may become a target organ for damage by non-essential metals, including mercury, lead, cadmium, chromium, and platinum and metalloids such as arsenic.
These differences in spleen and kidney radioactivity between 64 Cu-Pt NPs and 64 Cu-SA may be due to the differences in size, which would lead to a. Clinically, response to platinum treatment in patients with ovarian cancer is measured as the length of time from treatment to relapse, known as the platinum-free interval (PFI; ref.
PFI, however, is a crude measure of drug sensitivity (6) and is particularly poor at predicting response for patients identified as “partially sensitive.”. 1. Introduction. Acute kidney injury (AKI) is defined as a clinical syndrome characterized by a rapid decrease in renal function together with the accumulation of waste products such as urea .The incidence of non-dialysis-requiring AKI is about cases per million people per year and incidence of dialysis requiring AKI is cases per million people per year .
Platinum is a chemical element with the symbol Pt and atomic number It is a dense, malleable, ductile, highly unreactive, precious, silverish-white transition name is derived from the Spanish term platino, meaning "little silver". Platinum is a member of the platinum group of elements and group 10 of the periodic table of has six naturally occurring isotopes.
Measurements of Gluconeogenesis From Gene Expression. Many basic scientists have extrapolated changes in gluconeogenesis from the mRNA expression of key gluconeogenic enzymes such as glucosephosphatase and PEPCK in ex vivo experiments using murine and human liver biopsy specimens ().However, the process of converting potential gluconeogenic substrates to glucose is far more complex.
The effect of LC(50) ( mg/L) and a sublethal concentration ( mg/L) of in vivo mercuric chloride exposure on the activities of acid and alkaline phosphatases, glucosephosphatase, lipase and urease in the kidneys and ovaries of a teleost fish, Channa punctatus has.
Blood lead measurements are preferred to evaluate lead exposure. Thus, a second limitation of the study is that urine lead measurements are more variable than blood levels [ 21 ].
It is possible that blood lead with less intra-individual variability may show different patterns in smoke-exposed individuals.
3. Dietary Acids and Bases. Food and endogenous metabolic processes are the sources of acid or base intake or production. Studies on the effects of diet on urinary pH and acid excretion to alter acid-base balance started at the end of the 19th century [5,6,7].Subjects in these early studies would be fed specific diets and the urine analyzed for nitrogen compounds such as urea, non-urea.
In vitro corrosion measurements Immersion tests. After an observation time of h the AZ91D samples gained in weight an average of ± mg which was caused by the formation adherent corrosion products on the sample surface, while on the other hand, the LAE samples were completely corroded after 24 h of immersion.
Gary Curhan, in National Kidney Foundation Primer on Kidney Diseases (Sixth Edition), Scope of the Problem. Nephrolithiasis is a major cause of morbidity involving the urinary tract. The prevalence of nephrolithiasis in the U.S. population increased from % in the late s to % in the late s.
In our previous post, we outlined the dangers of Cytokine Release Syndrome (CRS) and the importance of preclinical Cytokine Release Assays (CRAs) when developing monoclonal antibodies (mAbs) that interact with the patient’s immune system.
In this second post, we describe the different kinds of assays in use and how these .The kidneys are at the back of the abdominal cavity, with one sitting on each side of the spine.
The right kidney is generally slightly smaller and lower than the left, to make space for the liver.